Detailed view for EgrG_000343000

Basic information

TDR Targets ID: 578511
Echinococcus granulosus, neurogenic locus notch protein
Source Database / ID:  GeneDB

pI: 6.2103 | Length (AA): 3082 | MW (Da): 338961 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00054   Laminin G domain
PF00400   WD domain, G-beta repeat
PF02210   Laminin G domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 16 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
281 982 5xau (A) 2679 3267 17.00 0.0000000009 0.9 0.0681742 1.21
363 1280 3qcw (A) 294 1133 21.00 0 1 0.350259 0.59
586 752 3pve (A) 1456 1627 18.00 0 1 0.439586 -1.34
598 1186 5mc9 (A) 2140 2656 20.00 0 1 0.14051 1.02
1124 1199 3eot (H) 57 146 39.00 0.75 0.38 0.0953593 1.79
1300 1350 4bdx (A) 31 80 38.00 0.012 1 0.509248 -0.41
1317 1424 4d90 (A) 26 155 40.00 0.0000000029 1 0.219742 0.27
1346 1598 4xbm (B) 185 431 36.00 0 1 0.27279 1.11
1869 1905 5vc1 (A) 117 153 43.00 0.061 1 0.599705 -0.66
1986 2022 5l0v (B) 5 40 53.00 0.0033 1 0.723705 -1.1
2239 2279 5l0r (B) 452 491 33.00 0.2 1 0.469703 -0.65
2241 2278 5kxh (B) 89 125 35.00 0.31 0.99 0.42373 -0.01
2642 2997 5nnz (B) 101 415 26.00 0.000000046 1 0.252209 0.45
2929 3007 4ycz (A) 20 102 38.00 0.0097 1 0.484333 -0.37
2938 3002 4lg8 (A) 233 297 34.00 0.0078 1 0.55379 -1.01
2941 3008 5nuv (A) 380 445 42.00 0.0000037 1 0.567764 -0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_152692)

Species Accession Gene Product
Echinococcus granulosus EgrG_000343000   neurogenic locus notch protein
Echinococcus multilocularis EmuJ_000343000   neurogenic locus notch protein
Giardia lamblia GL50803_6372   High cysteine protein
Schistosoma japonicum Sjp_0071970   Neurexin-3-alpha precursor, putative
Schistosoma japonicum Sjp_0071980   IPR001680,WD-40 repeat;IPR011047,Quinonprotein alcohol dehydrogenase-like,domain-containing
Schistosoma japonicum Sjp_0306370   Uncharacterized WD repeat-containing protein all2124, putative
Schistosoma mansoni Smp_130280   cell polarity protein
Schmidtea mediterranea mk4.019546.00  
Schmidtea mediterranea mk4.000555.02  
Schmidtea mediterranea mk4.024884.01  
Schmidtea mediterranea mk4.000555.03  
Schmidtea mediterranea mk4.024884.00   Cell polarity protein
Theileria parva TP01_1178   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0029 1 1
0.0027 0.4212 1
0.0025 1 1
0.0078 0.3631 0.2694
0.0029 1 1
0.0026 0.435 1
0.0023 0.5 0.5
0.0054 0.5 0.5
0.0218 0.3656 0.3656
0.0024 0.5 0.5
0.0026 1 1
0.0049 0.2501 0.2501
0.0077 1 1
0.0028 0.5 0.5
0.0115 0.3005 0.3005
0.0028 0.5 0.5
0.0078 0.3631 0.2694
0.0345 0.4313 0.4313
0.0025 0.5 0.5
0.0027 0.4212 1
0.0078 0.3631 0.2694
0.0277 0.3252 0.3252
0.0025 0.3891 0.3891
0.00203233 1 1
0.0173 0.4278 0.4277
0.0027 1 1
0.0046 0.3702 0.5241
0.0218 0.3656 0.3656
0.0051 1 0.5
0.0277 0.3252 0.3252

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000343000 (Echinococcus granulosus), neurogenic locus notch protein
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